Remember, this is educational information only and not medical advice – always check with your qualified medical professional before making any changes to your diet or treatment plan for endometriosis or any other health problems.


This GnRh drug is commonly prescribed by misinformed doctors as a treatment for endometriosis. However, it cannot diagnose, treat, remove, or shrink endometriosis lesions. What it may do is provide symptom management only (although many patients find the drug side effects intolerable). It can also cause long-term, irreversible side effects that many doctors are not discussing with patients, oftentimes because they are not aware of them. Many people who take Lupron later say, “I wish I had known XYZ about Lupron before taking it.” For this reason, we did a five part series on Lupron and Orilissa (an oral GnRh drug that came out in 2018.)

If you decide that taking Lupron is right for you, then we hope it provides you symptom relief! However, make sure to adequately research Lupron to see if you feel that the potential benefits outweigh the potential risks of taking this serious medication.

For many gynecologists, who are not endometriosis specialists and don’t often see patients with endometriosis in their practice, this (and/or Orilissa) is the only “tool” they have for patients with endometriosis. GnRh drugs are supposed to be second-line therapies, meaning that they are prescribed when first-line therapies (oral contraceptive pills and progestins) are ineffective, not tolerated or contraindicated. Studies have shown that in about 2/3 of people with endometriosis, first-line therapies provide symptom relief.
Yet some doctors put their patients on GnRh drugs right away, as soon as they suspect endometriosis, and for much longer than the FDA approved time frame. Additionally, various studies comparing GnRh drugs to other hormonal medications such as the Mirena, Dienogest, Depo Provera, combined birth control pills, and others, have shown these other hormones (which a patient can be on for longer and that have a much lower side effect profile) to provide similar symptom relief to patients as GnRh drugs. This is another reason why GnRh drugs are second-line therapies, but unfortunately many gynecologists are giving them out as soon as they suspect endometriosis, without any conversation around the side effects, treatment time limitations, or equally viable options.

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