Updated 1/2023. In part 2, we talk about how endometriosis is different from the endometrium in terms of its estrogen and progesterone receptors. These directly affect the biological processes of the endometriotic tissue, causing it to act differently than the endometrium does in response to estrogen and progesterone, ultimately leading to… you guessed it! Pain and inflammation!

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SOURCES: Clickable links at insixteenyears.com/episode57

—Is endometriosis an autotransplant? – From Endopaedia.info. You can see a chart of differences between endo and the endometrium.

–Marquardt RM, Kim TH, Shin JH, Jeong JW. Progesterone and Estrogen Signaling in the Endometrium: What Goes Wrong in Endometriosis? Int J Mol Sci. 2019;20(15):3822. Published 2019 Aug 5. doi:10.3390/ijms20153822 – There is also a chart of differences of endo and the endometrium here.

–Bulun SE, Yilmaz BD, Sison C, et al. Endometriosis. Endocr Rev. 2019;40(4):1048-1079. doi:10.1210/er.2018-00242

—David Redwine, MD – Dr. Redwine’s talk on HOX genes.

–Bulun SE, Monsavais D, Pavone ME, et al. Role of estrogen receptor-β in endometriosis. Semin Reprod Med. 2012;30(1):39-45. doi:10.1055/s-0031-1299596

—Progesterone Resistance in Endometriosis – Article on Nancy’s Nook.

–Bulun SE, Cheng YH, Pavone ME, et al. 17Beta-hydroxysteroid dehydrogenase-2 deficiency and progesterone resistance in endometriosis. Semin Reprod Med. 2010;28(1):44-50. doi:10.1055/s-0029-1242992