Ep55: Endometriosis and Estrogen

Updated 1/2024. We talk about some of the roles that estrogen can play in endometriosis and how it can make it’s own localized estrogen. We dispel the myth of retrograde menstruation and discuss why mouse endometriosis models are problematic. We also discuss the myths that everyone with endometriosis is estrogen dominant (not true!) or that medical or natural menopause will treat the disease (not true!).

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SOURCES: Clickable links at insixteenyears.com/episode55

–Bulun SE, Monsavais D, Pavone ME, et al. Role of estrogen receptor-β in endometriosis. Semin Reprod Med. 2012;30(1):39-45. doi:10.1055/s-0031-1299596

–Serdar E Bulun, Bahar D Yilmaz, Christia Sison, Kaoru Miyazaki, Lia Bernardi, Shimeng Liu, Amanda Kohlmeier, Ping Yin, Magdy Milad, JianJun Wei, Endometriosis, Endocrine Reviews, Volume 40, Issue 4, August 2019, Pages 1048–1079, https://doi.org/10.1210/er.2018-00242

Endometriosis in Males – By Wendy Bingham from ExtraPelvic Not Rare

Helpful table about hormonal balance symptoms – A list of the functions of estrogen in the body and symptoms of high or low estrogen

Endometriosis persisting after hysterectomy and bilateral salpingo-oophorectomy: Removing the disease, not organs, is key to long-term relief – Article from Endopaedia.info

Reason Why Hormone Therapy Alone Cannot Cure Endometriosis Uncovered – Quick summary of a research article on hormone receptors

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